Moxifloxacin (Avelox) and Ketamine Therapy | Tovani Health
Avelox (Moxifloxacin) — Fluoroquinolone antibiotic
Verdict at Tovani Health
Fully compatible; ketamine itself does not meaningfully prolong QT.
Moxifloxacin and ketamine have no clinically significant interaction. Moxifloxacin has the highest intrinsic QT prolongation of the fluoroquinolone class — used as the positive control in QT studies. That QT effect is moxifloxacin's own; ketamine at psychiatric doses is not a meaningful QT-prolonging drug per the published literature, so the combination is not a 'stacking' interaction.
If you take Avelox regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Avelox interacts with ketamine
Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV. Modest QT prolongation independent of ketamine. Hepatic metabolism with minor CYP effects.
What we do at intake
Continue your course as prescribed. Tell us about other QT-prolonging medications, which is a moxifloxacin concern more than a KAP concern.
Bottom line
Moxifloxacin and ketamine have no clinically significant interaction. Moxifloxacin has the highest intrinsic QT prolongation of the fluoroquinolone class — used as the positive control in QT studies. That QT effect is moxifloxacin's own; ketamine at psychiatric doses is not a meaningful QT-prolonging drug per the published literature, so the combination is not a 'stacking' interaction.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Avelox (Moxifloxacin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.