Medroxyprogesterone (Provera, Depo-Provera) and Ketamine Therapy | Tovani Health
Provera (oral) (Medroxyprogesterone) (also: Depo-Provera (IM injection), Depo-SubQ Provera 104) — Synthetic progestin (HRT, contraception, abnormal uterine bleeding, endometriosis)
Verdict at Tovani Health
Fully compatible with KAP across all formulations.
Medroxyprogesterone and ketamine have no clinically significant interaction. Used as oral Provera (cyclic HRT progestin, abnormal uterine bleeding) and as Depo-Provera (long-acting injectable contraception every 12-13 weeks). The intrinsic considerations — bone density decline with long-term Depo use, return-to-fertility delay after discontinuation, mood and weight effects — are progestin-class issues independent of KAP.
If you take Provera (oral) regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Provera (oral) interacts with ketamine
Synthetic progestin acting at progesterone receptors. Hepatic CYP3A4 metabolism (substrate). No clinically significant reciprocal effect on ketamine.
What we do at intake
Continue as prescribed.
Bottom line
Medroxyprogesterone and ketamine have no clinically significant interaction. Used as oral Provera (cyclic HRT progestin, abnormal uterine bleeding) and as Depo-Provera (long-acting injectable contraception every 12-13 weeks). The intrinsic considerations — bone density decline with long-term Depo use, return-to-fertility delay after discontinuation, mood and weight effects — are progestin-class issues independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Provera (oral) (Medroxyprogesterone) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.