Magnesium and Ketamine Therapy | Tovani Health
Magnesium Glycinate (Magnesium) (also: Magnesium Citrate, Magnesium Oxide) — Mineral supplement
Verdict at Tovani Health
Fully compatible; no meaningful interaction.
Magnesium and ketamine have no clinically significant interaction. Common for sleep, constipation, muscle cramps, or migraine prophylaxis. Continue as you normally would.
If you take Magnesium Glycinate regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Magnesium Glycinate interacts with ketamine
Magnesium is an essential mineral involved in hundreds of enzymatic reactions. NMDA receptor activity is modulated by magnesium (magnesium normally blocks the channel at rest, ketamine works at a different binding site), but supplemental magnesium does not change ketamine's clinical effect at typical doses.
What we do at intake
Continue as normal. Disclose if you take very high doses or have a history of magnesium-related issues.
Bottom line
Magnesium and ketamine have no clinically significant interaction. Common for sleep, constipation, muscle cramps, or migraine prophylaxis. Continue as you normally would.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Magnesium Glycinate (Magnesium) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.