LSD and Ketamine Therapy | Tovani Health
Acid (LSD) — Serotonergic psychedelic (5-HT2A agonist; DEA Schedule I)
Verdict at Tovani Health
Federally illegal; no documented combination harm with ketamine, but we space sessions from any active use.
LSD is a DEA Schedule I controlled substance in the United States. There is essentially no published evidence of LSD plus ketamine combination harm. Our position is precautionary and pragmatic rather than evidence-driven: we do not run a ketamine session while LSD is active or in the recovery window because the experiential load is heavy and the serotonergic stacking, while small, is real. Recent recreational LSD use does not permanently disqualify you from KAP. We discuss the use pattern and plan session timing.
If you take Acid regularly and are considering at-home ketamine therapy, the combination is depends on your specific situation. This page covers the brief pharmacologic context and what we do at intake.
How Acid interacts with ketamine
LSD agonizes 5-HT2A serotonin receptors with a long duration of action (8 to 12 hours of active effect, with subjective afterglow for 24 to 48 hours). Ketamine works at NMDA receptors. Mechanisms are different but the simultaneous psychological load is significant and the serotonergic axis is non-trivial.
What we do at intake
Disclose any recent LSD use. We ask for at least 7 days between any LSD experience and a ketamine session. Microdosing protocols (low-dose LSD every few days) require individual discussion. We are not an enforcement service and will not report disclosed use; honest answers let us plan safely.
Bottom line
LSD is a DEA Schedule I controlled substance in the United States. There is essentially no published evidence of LSD plus ketamine combination harm. Our position is precautionary and pragmatic rather than evidence-driven: we do not run a ketamine session while LSD is active or in the recovery window because the experiential load is heavy and the serotonergic stacking, while small, is real. Recent recreational LSD use does not permanently disqualify you from KAP. We discuss the use pattern and plan session timing.
Frequently Asked Questions
Is microdosing LSD an issue for KAP?
We discuss it individually. Microdosing protocols vary, and the daily-low-dose pattern interacts differently than a single full dose.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Acid (LSD) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Psychedelics. Nichols DE. Pharmacological Reviews. 2016. PMID: 26841800
Landmark pharmacology review covering LSD pharmacology and duration of action.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 16, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.