Losartan (Cozaar) and Ketamine Therapy | Tovani Health
Cozaar (Losartan) — Angiotensin II receptor blocker (ARB)
Verdict at Tovani Health
Fully compatible with KAP; same profile as lisinopril.
Losartan and ketamine have no clinically significant interaction. ARBs have the same clean ketamine-compatibility profile as ACE inhibitors. Standard session-day BP measurement applies to every KAP patient regardless of antihypertensive use.
If you take Cozaar regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Cozaar interacts with ketamine
Losartan blocks angiotensin II receptors, reducing vascular tone. Same interaction profile with ketamine as ACE inhibitors.
What we do at intake
Disclose dose. We check BP before and after the session and watch for orthostasis on standing.
Bottom line
Losartan and ketamine have no clinically significant interaction. ARBs have the same clean ketamine-compatibility profile as ACE inhibitors. Standard session-day BP measurement applies to every KAP patient regardless of antihypertensive use.
Frequently Asked Questions
Do I need to stop Cozaar before a session?
No. Continue your normal regimen.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Cozaar (Losartan) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Blood pressure safety of subanesthetic ketamine for depression: A report on 684 infusions. Riva-Posse P, Reiff CM, Edwards JA, et al.. Journal of Affective Disorders. 2018. PMID: 29525051
684-infusion case series documenting transient blood pressure elevation as the most common cardiovascular effect of subanesthetic ketamine; no serious adverse cardiovascular events.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 16, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.