Lisinopril and Ketamine Therapy | Tovani Health
Prinivil (Lisinopril) (also: Zestril) — ACE inhibitor (antihypertensive)
Verdict at Tovani Health
Fully compatible with KAP; no ketamine-specific interaction.
Lisinopril and ketamine have no clinically significant interaction. ACE inhibitors have no CYP overlap, no QT effect, no CNS depression. The BP measurement at the start and end of a session is standard for every KAP patient, not specific to ACE-inhibitor users. Continue your medication as normal.
If you take Prinivil regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Prinivil interacts with ketamine
Lisinopril inhibits angiotensin-converting enzyme, reducing systemic vascular resistance. Ketamine produces transient sympathomimetic activation. The net effect on BP during a session depends on the patient's baseline and hydration status.
What we do at intake
Tell us the dose and any history of orthostatic symptoms or syncope. We check BP at start and end of each session and have you sit before standing.
Bottom line
Lisinopril and ketamine have no clinically significant interaction. ACE inhibitors have no CYP overlap, no QT effect, no CNS depression. The BP measurement at the start and end of a session is standard for every KAP patient, not specific to ACE-inhibitor users. Continue your medication as normal.
Frequently Asked Questions
Should I skip my morning lisinopril on session day?
Usually no. We typically keep antihypertensives on board and monitor BP during the session.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Prinivil (Lisinopril) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Blood pressure safety of subanesthetic ketamine for depression: A report on 684 infusions. Riva-Posse P, Reiff CM, Edwards JA, et al.. Journal of Affective Disorders. 2018. PMID: 29525051
684-infusion case series documenting transient blood pressure elevation as the most common cardiovascular effect of subanesthetic ketamine; no serious adverse cardiovascular events.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 16, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.