Lisdexamfetamine (Vyvanse) and Ketamine Therapy | Tovani Health
Vyvanse (Lisdexamfetamine) — Stimulant (ADHD)
Verdict at Tovani Health
Compatible; cardiovascular load is what we track.
Lisdexamfetamine and ketamine are compatible. Ketamine briefly raises BP and HR during a session; stimulants raise baseline BP and HR. The two stack on the cardiovascular axis, which matters most for patients with hypertension or known arrhythmia.
If you take Vyvanse regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Vyvanse interacts with ketamine
Lisdexamfetamine is a prodrug of dextroamphetamine, which increases dopamine and norepinephrine release. Ketamine produces transient sympathomimetic activation. The combined cardiovascular effect is additive, not synergistic.
What we do at intake
Disclose dose and timing. We typically run sessions in the morning before the stimulant peaks, or several hours after it has worn off. Baseline EKG if you have a cardiac history.
Bottom line
Lisdexamfetamine and ketamine are compatible. Ketamine briefly raises BP and HR during a session; stimulants raise baseline BP and HR. The two stack on the cardiovascular axis, which matters most for patients with hypertension or known arrhythmia.
Frequently Asked Questions
Should I skip Vyvanse on session days?
Often yes, especially in the early sessions. We coordinate timing during your intake.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Vyvanse (Lisdexamfetamine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Blood pressure safety of subanesthetic ketamine for depression: A report on 684 infusions. Riva-Posse P, Reiff CM, Edwards JA, et al.. Journal of Affective Disorders. 2018. PMID: 29525051
684-infusion case series documenting transient blood pressure elevation as the most common cardiovascular effect of subanesthetic ketamine; no serious adverse cardiovascular events.
- Pharmacodynamic Interactions Between Ketamine and Psychiatric Medications Used in the Treatment of Depression: A Systematic Review. Veraart JKE, Smith-Apeldoorn SY, Bakker IM, et al.. International Journal of Neuropsychopharmacology. 2021. PMID: 34170315
Systematic review of pharmacodynamic interactions between ketamine and psychiatric medications used in depression treatment.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 15, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.