Levonorgestrel IUD (Mirena, Kyleena) and Ketamine Therapy | Tovani Health
Mirena (Levonorgestrel IUD) (also: Kyleena, Skyla, Liletta) — Progestin-only intrauterine device
Verdict at Tovani Health
Fully compatible with KAP.
Levonorgestrel IUDs and ketamine have no clinically significant interaction. The IUD releases progestin locally with minimal systemic absorption, much lower than oral progestins. Continue your contraception as you normally would.
If you take Mirena regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Mirena interacts with ketamine
The IUD releases levonorgestrel directly into the uterine cavity. Systemic plasma levels are roughly 1/10th to 1/100th of oral progestin-only pills. No CYP or other interaction relevant to ketamine.
What we do at intake
Continue as normal. Note the type and placement date during intake.
Bottom line
Levonorgestrel IUDs and ketamine have no clinically significant interaction. The IUD releases progestin locally with minimal systemic absorption, much lower than oral progestins. Continue your contraception as you normally would.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Mirena (Levonorgestrel IUD) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.