Lemborexant (Dayvigo) and Ketamine Therapy | Tovani Health
Dayvigo (Lemborexant) — Dual orexin receptor antagonist (DORA, sleep)
Verdict at Tovani Health
Compatible; same residual-sedation profile as Belsomra.
Lemborexant and ketamine are compatible. Same DORA mechanism and considerations as suvorexant (Belsomra): next-morning residual sedation can stack with a morning session.
If you take Dayvigo regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Dayvigo interacts with ketamine
Lemborexant blocks orexin OX1 and OX2 receptors, reducing wakefulness signaling. Half-life around 17 hours produces measurable next-day effect for many patients.
What we do at intake
Tell us the dose and time you typically take it. Afternoon sessions may be preferable.
Bottom line
Lemborexant and ketamine are compatible. Same DORA mechanism and considerations as suvorexant (Belsomra): next-morning residual sedation can stack with a morning session.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Dayvigo (Lemborexant) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.