Latanoprost (Xalatan) and Ketamine Therapy | Tovani Health
Xalatan (Latanoprost) — Topical prostaglandin analog (glaucoma)
Verdict at Tovani Health
Fully compatible; topical eye drop with minimal systemic absorption.
Latanoprost and ketamine have no clinically significant interaction. Once-daily evening eye drop for glaucoma (open-angle and ocular hypertension). Local delivery with negligible systemic absorption. The cosmetic side effects (eyelash growth, iris pigmentation darkening) are intrinsic to the prostaglandin class.
If you take Xalatan regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Xalatan interacts with ketamine
Latanoprost is a prostaglandin F2α analog that increases uveoscleral aqueous outflow. Hydrolyzed locally in the cornea. Minimal systemic absorption.
What we do at intake
Continue as prescribed. Use the punctal-occlusion technique to maximize ocular and minimize systemic exposure.
Bottom line
Latanoprost and ketamine have no clinically significant interaction. Once-daily evening eye drop for glaucoma (open-angle and ocular hypertension). Local delivery with negligible systemic absorption. The cosmetic side effects (eyelash growth, iris pigmentation darkening) are intrinsic to the prostaglandin class.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Xalatan (Latanoprost) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.