Lasmiditan (Reyvow) and Ketamine Therapy | Tovani Health
Reyvow (Lasmiditan) — 5HT1F receptor agonist 'ditan' (acute migraine)
Verdict at Tovani Health
Fully compatible; the receptor selectivity gives a much lower SS risk than the older triptans.
Lasmiditan and ketamine have no clinically significant interaction. The newer 'ditan' class is selective for 5HT1F receptors (no 1B/1D activity), which eliminates the vasoconstrictor concerns that limit triptans in cardiovascular disease and substantially reduces theoretical serotonin syndrome stacking compared to non-selective serotonergics. CNS side effects (dizziness, somnolence) are prominent — the 8-hour driving prohibition after each dose is intrinsic to lasmiditan and unrelated to KAP, though obviously relevant if a dose is taken close to a session.
If you take Reyvow regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Reyvow interacts with ketamine
Lasmiditan selectively activates neuronal 5HT1F receptors, inhibiting trigeminal pain signaling. Minimal cardiovascular activity. CYP-independent metabolism.
What we do at intake
Disclose use. Don't take lasmiditan within 8 hours of your KAP session (driving prohibition + CNS-effect stacking).
Bottom line
Lasmiditan and ketamine have no clinically significant interaction. The newer 'ditan' class is selective for 5HT1F receptors (no 1B/1D activity), which eliminates the vasoconstrictor concerns that limit triptans in cardiovascular disease and substantially reduces theoretical serotonin syndrome stacking compared to non-selective serotonergics. CNS side effects (dizziness, somnolence) are prominent — the 8-hour driving prohibition after each dose is intrinsic to lasmiditan and unrelated to KAP, though obviously relevant if a dose is taken close to a session.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Reyvow (Lasmiditan) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.