L-Citrulline (and Citrulline Malate) and Ketamine Therapy | Tovani Health
Citrulline malate (L-Citrulline) (also: Watermelon extract) — Amino acid (NO precursor — bioavailability advantage over L-arginine)
Verdict at Tovani Health
Fully compatible — same NO-precursor pathway as L-arginine; clinical effect is modest.
L-citrulline and ketamine have no clinically significant interaction. Citrulline is converted to arginine in the kidneys, bypassing first-pass arginase metabolism and delivering arginine more efficiently than oral arginine. Same NO/vasodilation framework — clinically modest. Common pre-workout supplement and used for erectile function and circulation. Often combined with malate as 'citrulline malate' for additional ATP-cycle support.
If you take Citrulline malate regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Citrulline malate interacts with ketamine
L-citrulline converts to L-arginine via argininosuccinate synthase/lyase. Higher oral bioavailability than direct arginine. Downstream effects identical (NO → vasodilation).
What we do at intake
Continue as you normally take it.
Bottom line
L-citrulline and ketamine have no clinically significant interaction. Citrulline is converted to arginine in the kidneys, bypassing first-pass arginase metabolism and delivering arginine more efficiently than oral arginine. Same NO/vasodilation framework — clinically modest. Common pre-workout supplement and used for erectile function and circulation. Often combined with malate as 'citrulline malate' for additional ATP-cycle support.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Citrulline malate (L-Citrulline) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.