Ketorolac (Toradol) and Ketamine Therapy | Tovani Health
Toradol (Ketorolac) (also: Sprix) — NSAID (parenteral/oral/nasal/ophthalmic)
Verdict at Tovani Health
Fully compatible with KAP.
Ketorolac and ketamine have no clinically significant interaction. Most commonly used as IV/IM Toradol for acute pain (post-op, ER kidney stone, severe headache) — the 5-day duration limit is intrinsic to ketorolac's GI/renal toxicity profile, not a KAP concern. Sometimes used alongside KAP in pain medicine for opioid-sparing protocols.
If you take Toradol regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Toradol interacts with ketamine
Ketorolac is a potent non-selective COX inhibitor. Strong analgesic effect comparable to opioids for many indications. No CYP interactions with ketamine.
What we do at intake
Continue as prescribed within the recommended duration limits.
Bottom line
Ketorolac and ketamine have no clinically significant interaction. Most commonly used as IV/IM Toradol for acute pain (post-op, ER kidney stone, severe headache) — the 5-day duration limit is intrinsic to ketorolac's GI/renal toxicity profile, not a KAP concern. Sometimes used alongside KAP in pain medicine for opioid-sparing protocols.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Toradol (Ketorolac) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.