Ivabradine (Corlanor) and Ketamine Therapy | Tovani Health
Corlanor (Ivabradine) — Funny-channel (If) inhibitor (heart rate reduction; HF, angina)
Verdict at Tovani Health
Compatible; CYP3A4 inhibitors meaningfully raise ivabradine levels — flag for KAP patients on those.
Ivabradine and ketamine are compatible. Ivabradine selectively lowers heart rate without affecting BP or contractility, used in heart failure and chronic angina. The relevant flag isn't a KAP interaction — it's that strong CYP3A4 inhibitors (clarithromycin, Paxlovid, itraconazole) substantially raise ivabradine levels and can cause bradycardia. Patients prescribed any of those alongside ivabradine need careful drug review.
If you take Corlanor regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Corlanor interacts with ketamine
Ivabradine inhibits the cardiac pacemaker funny current (If) at the sinoatrial node, lowering heart rate selectively. Major CYP3A4 substrate. No direct ketamine interaction.
What we do at intake
Disclose dose and indication. Tell us about all medications, especially any CYP3A4 inhibitors.
Bottom line
Ivabradine and ketamine are compatible. Ivabradine selectively lowers heart rate without affecting BP or contractility, used in heart failure and chronic angina. The relevant flag isn't a KAP interaction — it's that strong CYP3A4 inhibitors (clarithromycin, Paxlovid, itraconazole) substantially raise ivabradine levels and can cause bradycardia. Patients prescribed any of those alongside ivabradine need careful drug review.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Corlanor (Ivabradine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.