Hydralazine (Apresoline) and Ketamine Therapy | Tovani Health
Apresoline (Hydralazine) — Direct vasodilator antihypertensive
Verdict at Tovani Health
Fully compatible with KAP.
Hydralazine and ketamine have no clinically significant interaction. Used for resistant hypertension and heart failure (in combination with isosorbide for the BiDil indication in heart failure). Standard antihypertensive BP measurement applies to every KAP patient regardless of medication.
If you take Apresoline regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Apresoline interacts with ketamine
Hydralazine relaxes arteriolar smooth muscle. The exact mechanism is incompletely understood. No CYP interactions of clinical significance with ketamine.
What we do at intake
Continue as normal.
Bottom line
Hydralazine and ketamine have no clinically significant interaction. Used for resistant hypertension and heart failure (in combination with isosorbide for the BiDil indication in heart failure). Standard antihypertensive BP measurement applies to every KAP patient regardless of medication.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Apresoline (Hydralazine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.