Goserelin (Zoladex) and Ketamine Therapy | Tovani Health
Zoladex (Goserelin) — GnRH agonist (prostate cancer, breast cancer, endometriosis)
Verdict at Tovani Health
Fully compatible; same profile as leuprolide.
Goserelin and ketamine have no clinically significant interaction. Subcutaneous implant typically every 1 or 3 months. Same clean GnRH-agonist profile as leuprolide. Common alternative to leuprolide for prostate cancer (often combined with bicalutamide for combined androgen blockade) and used in premenopausal breast cancer.
If you take Zoladex regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Zoladex interacts with ketamine
Goserelin is a synthetic GnRH agonist. Continuous receptor stimulation suppresses LH/FSH and gonadal hormone output. Peptide drug — no CYP metabolism. No interaction with ketamine.
What we do at intake
Continue as scheduled. Tell us your last implant date.
Bottom line
Goserelin and ketamine have no clinically significant interaction. Subcutaneous implant typically every 1 or 3 months. Same clean GnRH-agonist profile as leuprolide. Common alternative to leuprolide for prostate cancer (often combined with bicalutamide for combined androgen blockade) and used in premenopausal breast cancer.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Zoladex (Goserelin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.