Golimumab (Simponi) and Ketamine Therapy | Tovani Health
Simponi (Golimumab) (also: Simponi Aria) — TNF-α monoclonal antibody (RA, PsA, AS, UC)
Verdict at Tovani Health
Fully compatible; same profile as adalimumab and infliximab.
Golimumab and ketamine have no clinically significant interaction. Subcutaneous monthly injection (Simponi) or IV every-8-week infusion (Simponi Aria) for RA, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Same clean TNF-α mAb profile as adalimumab, etanercept, infliximab, and certolizumab.
If you take Simponi regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Simponi interacts with ketamine
Golimumab is a fully human mAb against TNF-α. Cleared by reticuloendothelial system. No CYP interaction with ketamine.
What we do at intake
Continue as scheduled.
Bottom line
Golimumab and ketamine have no clinically significant interaction. Subcutaneous monthly injection (Simponi) or IV every-8-week infusion (Simponi Aria) for RA, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Same clean TNF-α mAb profile as adalimumab, etanercept, infliximab, and certolizumab.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Simponi (Golimumab) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.