Glyburide (DiaBeta) and Ketamine Therapy | Tovani Health
DiaBeta (Glyburide) (also: Micronase, Glynase) — Sulfonylurea antidiabetic (longer-acting)
Verdict at Tovani Health
Compatible; higher hypoglycemia risk than glipizide, especially with the KAP fasting window.
Glyburide and ketamine are compatible. The practical issue is hypoglycemia risk: glyburide has a longer half-life and active metabolites that produce more frequent and prolonged hypoglycemia than glipizide, especially in older patients. The Beers Criteria list glyburide as a medication to avoid in adults 65 and older. The pre-session fasting window for KAP compounds this — we work with you on dosing.
If you take DiaBeta regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How DiaBeta interacts with ketamine
Glyburide stimulates insulin release from pancreatic beta cells. Long half-life (10+ hours) and active hepatic metabolites prolong the effect. No direct ketamine PK interaction.
What we do at intake
Disclose dose and indication. Tell us your usual blood sugar pattern, especially morning fasting glucose. We may ask you to skip the morning dose on session day or reduce it.
Bottom line
Glyburide and ketamine are compatible. The practical issue is hypoglycemia risk: glyburide has a longer half-life and active metabolites that produce more frequent and prolonged hypoglycemia than glipizide, especially in older patients. The Beers Criteria list glyburide as a medication to avoid in adults 65 and older. The pre-session fasting window for KAP compounds this — we work with you on dosing.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on DiaBeta (Glyburide) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.