Glecaprevir-Pibrentasvir (Mavyret) and Ketamine Therapy | Tovani Health
Mavyret (Glecaprevir / Pibrentasvir) — Pangenotypic direct-acting antiviral combination (chronic Hep C)
Verdict at Tovani Health
Fully compatible with KAP; cure-focused short-course Hep C therapy.
Glecaprevir-pibrentasvir (Mavyret) and ketamine have no clinically significant interaction. Pangenotypic direct-acting antiviral combination — 8-12 weeks of oral therapy with high cure rates across HCV genotypes. The intrinsic interaction worth knowing about — Mavyret is contraindicated with rifampin and atazanavir-based regimens, and has reduced efficacy with strong CYP3A4 inducers — is HCV-therapy specific and independent of KAP.
If you take Mavyret regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Mavyret interacts with ketamine
Glecaprevir is an NS3/4A protease inhibitor; pibrentasvir is an NS5A inhibitor. Both predominantly biliary elimination. Glecaprevir is a P-gp/BCRP inhibitor with some CYP3A4 modulation, but no clinically significant interaction with ketamine.
What we do at intake
Continue your HCV cure regimen — don't interrupt for KAP. Disclose start and expected end dates.
Bottom line
Glecaprevir-pibrentasvir (Mavyret) and ketamine have no clinically significant interaction. Pangenotypic direct-acting antiviral combination — 8-12 weeks of oral therapy with high cure rates across HCV genotypes. The intrinsic interaction worth knowing about — Mavyret is contraindicated with rifampin and atazanavir-based regimens, and has reduced efficacy with strong CYP3A4 inducers — is HCV-therapy specific and independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Mavyret (Glecaprevir / Pibrentasvir) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.