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Single-dose antibiotic (uncomplicated UTI)Reviewed May 22, 2026

Fosfomycin (Monurol) and Ketamine Therapy | Tovani Health

Monurol (Fosfomycin) — Single-dose antibiotic (uncomplicated UTI)

Verdict at Tovani Health

Fully compatible; single-dose oral, no follow-up dosing.

Fosfomycin and ketamine have no clinically significant interaction. Single-sachet oral dose for uncomplicated UTI in women — useful alternative when nitrofurantoin or Bactrim isn't appropriate. One-and-done dosing means no ongoing PK considerations.

If you take Monurol regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.

How Monurol interacts with ketamine

Fosfomycin inhibits an early step in bacterial cell wall synthesis. Renally cleared and concentrated in urine. No CYP interactions with ketamine.

What we do at intake

Take the single dose as prescribed (mix the sachet contents in water on an empty stomach).

Bottom line

Fosfomycin and ketamine have no clinically significant interaction. Single-sachet oral dose for uncomplicated UTI in women — useful alternative when nitrofurantoin or Bactrim isn't appropriate. One-and-done dosing means no ongoing PK considerations.

Ready to find out if at-home ketamine fits your situation?

We’ll note that you’re on Monurol (Fosfomycin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.

Check eligibility (5 min, FL & NJ residents)

FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.

Clinically reviewed

Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.

This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.