Flecainide (Tambocor) and Ketamine Therapy | Tovani Health
Tambocor (Flecainide) — Class IC antiarrhythmic (sodium channel blocker)
Verdict at Tovani Health
Compatible; the cardiac substrate context matters more than KAP-specific stacking.
Flecainide and ketamine are compatible. The CAST trial's lesson — flecainide is pro-arrhythmic in patients with structural heart disease — shapes who's prescribed it (typically patients with structurally normal hearts using it for AFib or PSVT). Worth confirming the cardiac context for KAP. Modest CYP2D6 metabolism doesn't meaningfully affect ketamine.
If you take Tambocor regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Tambocor interacts with ketamine
Flecainide is a class IC antiarrhythmic blocking voltage-gated sodium channels. CYP2D6 substrate. The cardiac safety story is intrinsic to flecainide and unchanged by KAP.
What we do at intake
Disclose indication. Bring a recent EKG if you have one. Tell us about your cardiology context.
Bottom line
Flecainide and ketamine are compatible. The CAST trial's lesson — flecainide is pro-arrhythmic in patients with structural heart disease — shapes who's prescribed it (typically patients with structurally normal hearts using it for AFib or PSVT). Worth confirming the cardiac context for KAP. Modest CYP2D6 metabolism doesn't meaningfully affect ketamine.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Tambocor (Flecainide) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.