Feverfew and Ketamine Therapy | Tovani Health
Tanacetum parthenium (Feverfew) (also: MIG-99 (standardized extract)) — Migraine-prophylaxis herbal supplement
Verdict at Tovani Health
Fully compatible with KAP; the migraine-prevention evidence is modest but the supplement is clean.
Feverfew and ketamine have no clinically significant interaction. Used for migraine prophylaxis with modest supporting evidence (Cochrane reviews place it 'possibly effective'). Mechanism is unclear but may involve mild serotonin modulation and platelet effects — theoretically relevant in patients on serotonergics or anticoagulants, but no clinical reports of meaningful interactions with ketamine. Common use is 50-100mg daily of standardized extract (MIG-99) or fresh leaf.
If you take Tanacetum parthenium regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Tanacetum parthenium interacts with ketamine
Active sesquiterpene lactones (notably parthenolide) inhibit serotonin release from platelets and modulate prostaglandin synthesis. Theoretical antiplatelet activity is mild and clinically minimal. No CYP interaction with ketamine.
What we do at intake
Continue as prescribed by your migraine plan. Tell us if you're also on prescription migraine prophylaxis (gepants, CGRP biologics, topiramate).
Bottom line
Feverfew and ketamine have no clinically significant interaction. Used for migraine prophylaxis with modest supporting evidence (Cochrane reviews place it 'possibly effective'). Mechanism is unclear but may involve mild serotonin modulation and platelet effects — theoretically relevant in patients on serotonergics or anticoagulants, but no clinical reports of meaningful interactions with ketamine. Common use is 50-100mg daily of standardized extract (MIG-99) or fresh leaf.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Tanacetum parthenium (Feverfew) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.