Erenumab (Aimovig) and Ketamine Therapy | Tovani Health
Aimovig (Erenumab) — CGRP-receptor monoclonal antibody (migraine prevention)
Verdict at Tovani Health
Fully compatible; monoclonal antibodies don't interact via CYP.
Erenumab and ketamine have no clinically significant interaction. Monoclonal antibodies are cleared by the reticuloendothelial system, not CYP enzymes, so they don't have the kinds of drug interactions that small molecules do. Continue your monthly injection schedule.
If you take Aimovig regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Aimovig interacts with ketamine
Erenumab is a fully human IgG2 monoclonal antibody that blocks the CGRP receptor, preventing migraine. Monthly subcutaneous injection. No CYP, no small-molecule interaction surface.
What we do at intake
Continue as scheduled. Tell us your last injection date during intake for completeness.
Bottom line
Erenumab and ketamine have no clinically significant interaction. Monoclonal antibodies are cleared by the reticuloendothelial system, not CYP enzymes, so they don't have the kinds of drug interactions that small molecules do. Continue your monthly injection schedule.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Aimovig (Erenumab) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.