Drospirenone (Yaz, Yasmin, Slynd) and Ketamine Therapy | Tovani Health
Yaz (with ethinyl estradiol) (Drospirenone) (also: Yasmin (with ethinyl estradiol), Slynd (progestin-only), Beyaz) — Spironolactone-analog progestin (combined OC, progestin-only pill, HRT)
Verdict at Tovani Health
Fully compatible with KAP — the spironolactone-like K-sparing effect matters intrinsically.
Drospirenone-containing contraceptives and ketamine have no clinically significant interaction. Unique among contraceptive progestins because of its spironolactone-analog structure — provides anti-androgenic and weak diuretic/K-sparing effects (improves acne and PMDD symptoms). The intrinsic considerations — modest hyperkalemia risk especially with ACE inhibitors, ARBs, K-sparing diuretics, or chronic NSAIDs — are drospirenone-class issues independent of KAP. Combined drospirenone-ethinyl estradiol OCs carry the same general VTE and CYP3A4-inducer considerations as other combined OCs.
If you take Yaz (with ethinyl estradiol) regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Yaz (with ethinyl estradiol) interacts with ketamine
Synthetic progestin with anti-mineralocorticoid (spironolactone-like) and anti-androgenic activity. Hepatic CYP3A4 metabolism (substrate). No clinically significant reciprocal effect on ketamine.
What we do at intake
Continue as prescribed. Disclose other meds affecting potassium (ACE inhibitors, ARBs, spironolactone, K supplements).
Bottom line
Drospirenone-containing contraceptives and ketamine have no clinically significant interaction. Unique among contraceptive progestins because of its spironolactone-analog structure — provides anti-androgenic and weak diuretic/K-sparing effects (improves acne and PMDD symptoms). The intrinsic considerations — modest hyperkalemia risk especially with ACE inhibitors, ARBs, K-sparing diuretics, or chronic NSAIDs — are drospirenone-class issues independent of KAP. Combined drospirenone-ethinyl estradiol OCs carry the same general VTE and CYP3A4-inducer considerations as other combined OCs.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Yaz (with ethinyl estradiol) (Drospirenone) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.