Dronabinol (Marinol, Syndros) and Ketamine Therapy | Tovani Health
Marinol (Dronabinol) (also: Syndros) — Synthetic oral THC (FDA-approved for chemo nausea and AIDS-related anorexia)
Verdict at Tovani Health
Compatible; same considerations as cannabis but at a defined pharmaceutical dose.
Dronabinol and ketamine are compatible. Dronabinol is FDA-approved synthetic THC at predictable pharmaceutical doses — distinct from recreational cannabis where THC content varies wildly. Same considerations as cannabis (cardiovascular effects, cognitive impairment, sedation), but the predictable dosing makes session planning easier.
If you take Marinol regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Marinol interacts with ketamine
Dronabinol is synthetic delta-9-THC, the primary psychoactive cannabinoid. Same CB1 receptor activity as recreational cannabis. Hepatic CYP2C9 and CYP3A4 metabolism; minor effect on ketamine PK.
What we do at intake
Disclose dose and indication (chemo nausea, AIDS wasting, off-label uses). Tell us about timing — we typically schedule sessions outside the peak effect window.
Bottom line
Dronabinol and ketamine are compatible. Dronabinol is FDA-approved synthetic THC at predictable pharmaceutical doses — distinct from recreational cannabis where THC content varies wildly. Same considerations as cannabis (cardiovascular effects, cognitive impairment, sedation), but the predictable dosing makes session planning easier.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Marinol (Dronabinol) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.