Dorzolamide (Trusopt) and Ketamine Therapy | Tovani Health
Trusopt (Dorzolamide ophthalmic) (also: Cosopt (with timolol)) — Topical carbonic anhydrase inhibitor (glaucoma)
Verdict at Tovani Health
Fully compatible with KAP — minimal systemic absorption.
Topical dorzolamide and ketamine have no clinically significant interaction. Carbonic anhydrase inhibitor eye drop for glaucoma, often combined with timolol (Cosopt). Topical application has minimal systemic absorption — the systemic CA inhibitor concerns that apply to oral acetazolamide (metabolic acidosis, paresthesias) don't transfer to the eye drop.
If you take Trusopt regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Trusopt interacts with ketamine
Selective inhibitor of carbonic anhydrase II in the ciliary body, reducing aqueous humor production. Topical application with minimal systemic absorption.
What we do at intake
Continue as prescribed. Use punctal-occlusion technique after each drop.
Bottom line
Topical dorzolamide and ketamine have no clinically significant interaction. Carbonic anhydrase inhibitor eye drop for glaucoma, often combined with timolol (Cosopt). Topical application has minimal systemic absorption — the systemic CA inhibitor concerns that apply to oral acetazolamide (metabolic acidosis, paresthesias) don't transfer to the eye drop.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Trusopt (Dorzolamide ophthalmic) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.