Digoxin (Lanoxin) and Ketamine Therapy | Tovani Health
Lanoxin (Digoxin) — Cardiac glycoside
Verdict at Tovani Health
Compatible; the narrow therapeutic index is independent of KAP.
Digoxin and ketamine have no clinically significant interaction. The well-known digoxin precautions (narrow therapeutic index, drug interactions affecting blood levels) are unchanged by KAP.
If you take Lanoxin regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Lanoxin interacts with ketamine
Digoxin inhibits cardiac Na/K-ATPase. Used for heart failure and atrial fibrillation rate control. Renally cleared. No CYP interactions with ketamine.
What we do at intake
Continue as normal. Maintain your usual digoxin level monitoring.
Bottom line
Digoxin and ketamine have no clinically significant interaction. The well-known digoxin precautions (narrow therapeutic index, drug interactions affecting blood levels) are unchanged by KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Lanoxin (Digoxin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.