Dicyclomine (Bentyl) and Ketamine Therapy | Tovani Health
Bentyl (Dicyclomine) — Anticholinergic antispasmodic (IBS, GI motility)
Verdict at Tovani Health
Fully compatible; dicyclomine's anticholinergic effects are intrinsic, not a stacking concern with ketamine.
Dicyclomine and ketamine have no clinically significant interaction. Dicyclomine has well-known anticholinergic side effects (dry mouth, urinary retention, cognitive effects, falls in elderly), but those are intrinsic to dicyclomine and not amplified by ketamine. Ketamine itself does not have meaningful clinical anticholinergic activity (it actually causes hypersalivation, the opposite). Continue as prescribed for IBS or GI motility.
If you take Bentyl regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Bentyl interacts with ketamine
Dicyclomine antagonizes muscarinic acetylcholine receptors, reducing GI smooth muscle spasm. Independent anticholinergic side-effect profile. No meaningful ketamine PK interaction.
What we do at intake
Continue as prescribed. Tell us about any anticholinergic side effects so we can advise on hydration and orthostasis after sessions.
Bottom line
Dicyclomine and ketamine have no clinically significant interaction. Dicyclomine has well-known anticholinergic side effects (dry mouth, urinary retention, cognitive effects, falls in elderly), but those are intrinsic to dicyclomine and not amplified by ketamine. Ketamine itself does not have meaningful clinical anticholinergic activity (it actually causes hypersalivation, the opposite). Continue as prescribed for IBS or GI motility.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Bentyl (Dicyclomine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.