Dapsone (Aczone) and Ketamine Therapy | Tovani Health
Aczone (Dapsone) (also: Avlosulfon) — Sulfone antibiotic / anti-inflammatory (leprosy, PCP prophylaxis, dermatitis herpetiformis, topical acne)
Verdict at Tovani Health
Fully compatible; methemoglobinemia and hemolysis are dapsone's intrinsic concerns.
Dapsone and ketamine have no clinically significant interaction. Uses range from oral (leprosy, PCP prophylaxis in sulfa-allergic patients, dermatitis herpetiformis) to topical (acne). The intrinsic dapsone concerns — methemoglobinemia at higher doses, hemolytic anemia in G6PD-deficient patients — are unchanged by KAP.
If you take Aczone regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Aczone interacts with ketamine
Dapsone inhibits dihydropteroate synthase and has additional anti-inflammatory effects. Mild CYP3A4 and CYP2C9 metabolism; clinical effect on ketamine PK is minimal.
What we do at intake
Continue as prescribed. Tell us your dose and any history of G6PD deficiency. If you take oral dapsone, mention any recent G6PD or methemoglobin labs.
Bottom line
Dapsone and ketamine have no clinically significant interaction. Uses range from oral (leprosy, PCP prophylaxis in sulfa-allergic patients, dermatitis herpetiformis) to topical (acne). The intrinsic dapsone concerns — methemoglobinemia at higher doses, hemolytic anemia in G6PD-deficient patients — are unchanged by KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Aczone (Dapsone) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.