Clindamycin (Cleocin) and Ketamine Therapy | Tovani Health
Cleocin (Clindamycin) — Lincosamide antibiotic
Verdict at Tovani Health
Fully compatible with KAP.
Clindamycin and ketamine have no clinically significant interaction. Common for dental, skin/soft-tissue, and certain anaerobic infections. The well-known clindamycin precaution (C. difficile colitis risk) is intrinsic to the antibiotic and independent of KAP.
If you take Cleocin regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Cleocin interacts with ketamine
Clindamycin inhibits bacterial protein synthesis at the 50S ribosomal subunit. No CYP interactions of clinical significance with ketamine.
What we do at intake
Continue as prescribed. Tell us if you develop any GI symptoms during or after the course.
Bottom line
Clindamycin and ketamine have no clinically significant interaction. Common for dental, skin/soft-tissue, and certain anaerobic infections. The well-known clindamycin precaution (C. difficile colitis risk) is intrinsic to the antibiotic and independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Cleocin (Clindamycin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.