Cladribine (Mavenclad) and Ketamine Therapy | Tovani Health
Mavenclad (Cladribine) — Oral purine nucleoside analog (highly active relapsing MS)
Verdict at Tovani Health
Fully compatible; the short-course dosing regimen is intrinsic.
Cladribine and ketamine have no clinically significant interaction. Distinctive among MS DMTs for its short-course pulse dosing — two annual courses of 4-5 days each, with durable effect — rather than continuous therapy. The intrinsic considerations — lymphopenia monitoring, malignancy surveillance, contraception requirements — are cladribine-class issues independent of KAP.
If you take Mavenclad regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Mavenclad interacts with ketamine
Cladribine is a purine analog that preferentially depletes lymphocytes (especially memory B cells) via DNA chain termination. Renally cleared. No CYP interaction with ketamine.
What we do at intake
Continue per your neurologist's dosing schedule. Tell us where you are in the cycle and your recent CBC.
Bottom line
Cladribine and ketamine have no clinically significant interaction. Distinctive among MS DMTs for its short-course pulse dosing — two annual courses of 4-5 days each, with durable effect — rather than continuous therapy. The intrinsic considerations — lymphopenia monitoring, malignancy surveillance, contraception requirements — are cladribine-class issues independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Mavenclad (Cladribine) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.