Cisplatin (Platinol) and Ketamine Therapy | Tovani Health
Platinol (Cisplatin) — Platinum cytotoxic chemotherapy (testicular, ovarian, lung, head/neck, bladder cancer)
Verdict at Tovani Health
Fully compatible with KAP; nephrotoxicity, neuropathy, and ototoxicity are intrinsic.
Cisplatin and ketamine have no clinically significant interaction. One of the most active chemotherapy agents — backbone in testicular cancer (curative), and used across many solid tumors. The intrinsic considerations — nephrotoxicity (managed with aggressive hydration), severe nausea/vomiting (managed with NK1 + 5HT3 + dexamethasone), peripheral neuropathy, and ototoxicity — are platinum-class concerns. The neuropathy can complicate KAP sensory assessment, similar to paclitaxel.
If you take Platinol regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Platinol interacts with ketamine
DNA cross-linking via platinum-DNA adducts. Renally eliminated. No clinically significant CYP interaction with ketamine.
What we do at intake
Continue your chemo regimen. Tell us infusion schedule, recent kidney function (creatinine), and any neuropathy or hearing changes.
Bottom line
Cisplatin and ketamine have no clinically significant interaction. One of the most active chemotherapy agents — backbone in testicular cancer (curative), and used across many solid tumors. The intrinsic considerations — nephrotoxicity (managed with aggressive hydration), severe nausea/vomiting (managed with NK1 + 5HT3 + dexamethasone), peripheral neuropathy, and ototoxicity — are platinum-class concerns. The neuropathy can complicate KAP sensory assessment, similar to paclitaxel.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Platinol (Cisplatin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.