Chamomile and Ketamine Therapy | Tovani Health
Matricaria chamomilla (Chamomile) (also: Matricaria recutita) — Mild anxiolytic herb (apigenin, GABA-A modulator)
Verdict at Tovani Health
Fully compatible at typical tea/extract doses.
Chamomile and ketamine have no clinically significant interaction. Apigenin, chamomile's main flavonoid, has mild GABA-A receptor activity at very high concentrated extract doses, but tea-strength chamomile is well below any clinically relevant threshold. Continue as you normally would.
If you take Matricaria chamomilla regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Matricaria chamomilla interacts with ketamine
Apigenin binds the benzodiazepine site of GABA-A receptors at high concentrations, but oral bioavailability is low and tea-strength use does not produce meaningful CNS effects. Drug-drug interaction risk is essentially zero at culinary or tea doses.
What we do at intake
Continue as normal. Disclose if you take high-dose concentrated extracts.
Bottom line
Chamomile and ketamine have no clinically significant interaction. Apigenin, chamomile's main flavonoid, has mild GABA-A receptor activity at very high concentrated extract doses, but tea-strength chamomile is well below any clinically relevant threshold. Continue as you normally would.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Matricaria chamomilla (Chamomile) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.