Celecoxib (Celebrex) and Ketamine Therapy | Tovani Health
Celebrex (Celecoxib) — COX-2 selective NSAID
Verdict at Tovani Health
Fully compatible; selective COX-2 means lower GI risk than older NSAIDs.
Celecoxib and ketamine have no clinically significant interaction. The COX-2 selectivity reduces GI bleeding risk vs older NSAIDs; standard cardiovascular caution applies independent of KAP.
If you take Celebrex regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Celebrex interacts with ketamine
Celecoxib selectively inhibits COX-2. Metabolized by CYP2C9. Minimal effect on ketamine PK.
What we do at intake
Continue as needed. Disclose any chronic daily use.
Bottom line
Celecoxib and ketamine have no clinically significant interaction. The COX-2 selectivity reduces GI bleeding risk vs older NSAIDs; standard cardiovascular caution applies independent of KAP.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Celebrex (Celecoxib) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 17, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.