Canagliflozin (Invokana) and Ketamine Therapy | Tovani Health
Invokana (Canagliflozin) — SGLT2 inhibitor (diabetes, kidney, heart failure)
Verdict at Tovani Health
Fully compatible; same profile as empagliflozin and dapagliflozin.
Canagliflozin and ketamine have no clinically significant interaction. Same SGLT2-class compatibility as empagliflozin (Jardiance) and dapagliflozin (Farxiga). Continue as normal.
If you take Invokana regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Invokana interacts with ketamine
Canagliflozin blocks renal SGLT2, causing glycosuria with mild diuretic and BP-lowering effects. No CYP interactions with ketamine.
What we do at intake
Continue as normal. Stay well-hydrated on session day; tell us about any history of DKA.
Bottom line
Canagliflozin and ketamine have no clinically significant interaction. Same SGLT2-class compatibility as empagliflozin (Jardiance) and dapagliflozin (Farxiga). Continue as normal.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Invokana (Canagliflozin) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.