Bisoprolol (Zebeta) and Ketamine Therapy | Tovani Health
Zebeta (Bisoprolol) (also: Ziac) — Beta-1 selective blocker (heart failure, hypertension)
Verdict at Tovani Health
Fully compatible; same favorable cardiovascular pairing as metoprolol.
Bisoprolol and ketamine have no clinically significant interaction. One of the four beta-blockers with proven HFrEF mortality benefit (with metoprolol succinate, carvedilol, and nebivolol). Beta-1 selective with smooth long-acting profile. Like other beta blockers, opposes ketamine's transient sympathomimetic effect.
If you take Zebeta regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Zebeta interacts with ketamine
Bisoprolol selectively blocks beta-1 adrenergic receptors. Renal + hepatic elimination, no significant CYP interactions with ketamine.
What we do at intake
Continue as normal.
Bottom line
Bisoprolol and ketamine have no clinically significant interaction. One of the four beta-blockers with proven HFrEF mortality benefit (with metoprolol succinate, carvedilol, and nebivolol). Beta-1 selective with smooth long-acting profile. Like other beta blockers, opposes ketamine's transient sympathomimetic effect.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Zebeta (Bisoprolol) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 22, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.