Benralizumab (Fasenra) and Ketamine Therapy | Tovani Health
Fasenra (Benralizumab) — IL-5 receptor monoclonal antibody (severe eosinophilic asthma, EGPA)
Verdict at Tovani Health
Fully compatible; same eosinophil-depletion framework as mepolizumab.
Benralizumab and ketamine have no clinically significant interaction. Targets the IL-5 receptor (rather than IL-5 itself like mepolizumab) — depletes eosinophils more aggressively via antibody-dependent cellular cytotoxicity. Used for severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis. Subcutaneous injection every 8 weeks after loading.
If you take Fasenra regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Fasenra interacts with ketamine
Humanized mAb against IL-5 receptor alpha; engages NK cells via ADCC to deplete eosinophils. Cleared by reticuloendothelial system. No CYP interaction with ketamine.
What we do at intake
Continue as scheduled.
Bottom line
Benralizumab and ketamine have no clinically significant interaction. Targets the IL-5 receptor (rather than IL-5 itself like mepolizumab) — depletes eosinophils more aggressively via antibody-dependent cellular cytotoxicity. Used for severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis. Subcutaneous injection every 8 weeks after loading.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Fasenra (Benralizumab) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 23, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.