Apixaban (Eliquis) and Ketamine Therapy | Tovani Health
Eliquis (Apixaban) — Direct oral anticoagulant (factor Xa inhibitor)
Verdict at Tovani Health
Fully compatible with KAP; no meaningful interaction.
Apixaban and ketamine have no clinically significant interaction. Eliquis patients on it for atrial fibrillation or VTE prevention proceed with KAP without medication changes.
If you take Eliquis regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Eliquis interacts with ketamine
Apixaban directly inhibits factor Xa. Metabolized primarily by CYP3A4 (substrate, not inhibitor). Net effect on ketamine PK is negligible at standard dosing.
What we do at intake
Continue as normal. Tell us about any recent dose changes or bleeding events.
Bottom line
Apixaban and ketamine have no clinically significant interaction. Eliquis patients on it for atrial fibrillation or VTE prevention proceed with KAP without medication changes.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Eliquis (Apixaban) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 16, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.