Vitamin B12 and Ketamine Therapy | Tovani Health
Cyanocobalamin (Vitamin B12) (also: Methylcobalamin, Hydroxocobalamin) — Water-soluble vitamin
Verdict at Tovani Health
Fully compatible with KAP.
Vitamin B12 and ketamine have no clinically significant interaction. Common as supplement for low-B12, vegan/vegetarian diets, and metformin-related B12 depletion. Both oral and injectable forms are fine. Worth noting: recreational nitrous oxide use inactivates B12, so we screen for that separately.
If you take Cyanocobalamin regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.
How Cyanocobalamin interacts with ketamine
Vitamin B12 is essential for methylation reactions and DNA synthesis. No CYP interactions with ketamine.
What we do at intake
Continue as normal. Disclose any heavy nitrous oxide use (whippits) which can deplete B12.
Bottom line
Vitamin B12 and ketamine have no clinically significant interaction. Common as supplement for low-B12, vegan/vegetarian diets, and metformin-related B12 depletion. Both oral and injectable forms are fine. Worth noting: recreational nitrous oxide use inactivates B12, so we screen for that separately.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Cyanocobalamin (Vitamin B12) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.