Oxymorphone (Opana) and Ketamine Therapy | Tovani Health
Opana (Oxymorphone) — Potent opioid analgesic
Verdict at Tovani Health
Compatible with the same close-monitoring approach used for other potent opioids.
Oxymorphone and ketamine are compatible with appropriate monitoring. Oxymorphone is more potent than oxycodone (it's the active metabolite of oxycodone) and sits between morphine and hydromorphone in the potency hierarchy. Same considerations as those: additive respiratory depression and sedation, careful dose coordination.
If you take Opana regularly and are considering at-home ketamine therapy, the combination is safe with monitoring or dose adjustment. This page covers the brief pharmacologic context and what we do at intake.
How Opana interacts with ketamine
Oxymorphone is a semi-synthetic mu-opioid agonist. Higher potency than morphine. Reformulated extended-release product was discontinued in the US due to abuse concerns, but immediate-release and generic ER remain available.
What we do at intake
Disclose dose, formulation, and indication. Coordinate with your pain prescriber.
Bottom line
Oxymorphone and ketamine are compatible with appropriate monitoring. Oxymorphone is more potent than oxycodone (it's the active metabolite of oxycodone) and sits between morphine and hydromorphone in the potency hierarchy. Same considerations as those: additive respiratory depression and sedation, careful dose coordination.
Ready to find out if at-home ketamine fits your situation?
We’ll note that you’re on Opana (Oxymorphone) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.
FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.
Sources
The verdict and clinical guidance on this page are based on the following peer-reviewed literature and FDA prescribing information.
- Ketamine as an Adjunct to Opioids for Acute Pain in the Emergency Department: A Randomized Controlled Trial. Bell RF, Eccleston C, Kalso EA. Cochrane Database of Systematic Reviews. 2017. PMID: 28657160
Clinically reviewed
Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.
This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.