Depot progestin contraception (quarterly IM)Reviewed May 19, 2026

Depo-Provera and Ketamine Therapy | Tovani Health

Depo-Provera (Medroxyprogesterone Acetate (Depot)) (also: Depo-SubQ Provera 104) — Depot progestin contraception (quarterly IM)

Verdict at Tovani Health

Fully compatible with KAP.

Depo-Provera and ketamine have no clinically significant interaction. The quarterly injection provides steady-state progestin exposure that's higher than IUD but still without relevant ketamine interaction. Continue as scheduled.

If you take Depo-Provera regularly and are considering at-home ketamine therapy, the combination is generally safe at therapeutic doses. This page covers the brief pharmacologic context and what we do at intake.

How Depo-Provera interacts with ketamine

Medroxyprogesterone acetate is a depot progestin that suppresses ovulation for 3 months per injection. No CYP interactions relevant to ketamine.

What we do at intake

Continue as scheduled. Note the date of your last injection during intake.

Bottom line

Ready to find out if at-home ketamine fits your situation?

We’ll note that you’re on Depo-Provera (Medroxyprogesterone Acetate (Depot)) at intake. The eligibility check takes 5 minutes and gives you an honest answer about whether at-home ketamine fits your specific situation.

Check eligibility (5 min, FL & NJ residents)

FL and NJ residents only. Benjamin Soffer, DO — Tovani Health.

Clinically reviewed

Reviewed by Benjamin Soffer, DO on May 19, 2026. Dr. Soffer is a board-certified physician (American Board of Internal Medicine) licensed in Florida and New Jersey, prescribing at-home ketamine therapy through Tovani Health.

This page is general information about how this medication interacts with at-home ketamine therapy at Tovani Health. It is not a substitute for medical advice from your prescribing physician about your specific situation. Always discuss medication changes with the doctor who prescribed them.